Penicillin-streptomycin mixture is also commonly referred to as "double antibiotics". It is the most commonly used antibiotic in in vitro culture to prevent microbial contamination. Among them, penicillin can interfere with the synthesis of bacterial cell walls and is particularly effective against Gram-positive bacteria; while streptomycin can bind to the 30S subunit of bacterial ribosomes and inhibit the synthesis of bacterial proteins. It is effective against both Gram-negative and Gram-positive bacteria, but is particularly effective against Gram-negative bacteria. The combination of penicillin and streptomycin can prevent most bacterial contamination. However, penicillin solution is sensitive to temperature and pH, is easily degraded at room temperature, needs to be stored in a refrigerator, and is most stable at pH 6.0-6.5; while streptomycin is relatively stable and is most stable at pH 5.0-7.5.
Precautions
1. This product is sterilized by 0.1μm filtration;
2. When using this product, pay attention to aseptic operation to avoid contamination;
3. This product is a concentrated solution, please dilute it as needed before use;
4. It should not be placed at room temperature or stored at 4℃ for a long time;
5. Thaw at 2℃～8℃, shake well before use, avoid repeated freezing and thawing, and it is recommended to be packaged and frozen when the amount is small;
6. This product is only used for scientific research or further research, not for diagnosis and treatment.
